Delirium
Introduction
Delirium is an acute, fluctuating change in mental status characterised by inattention, disorganized thinking and altered levels of consciousness.
Delirium represents approximately 15 % of ED presentations of older adults. A diagnosis of delirium in the ED infers a 12-month mortality rate of up to 25% which is comparable to patients with sepsis or acute myocardial infarction
The fluctuating course of delirium helps differentiate it from miId cognitive impairment and dementia. Obtaining a collateral history to determine baseline cognition is essential in the diagnosis.
DSM 5 Criteria for Diagnosis
A disturbance in attention is evident with reduced ability to focus, sustain, or shift attention.
A change in cognition such as memory deficit, disorientation, language disturbance or the development of a perceptual disturbance not better accounted for by pre existing or evolving dementia
The disturbance evolves over a short period of time (hours to days), represents an acute change from baseline and tends to fluctuate over the course of the day.
There is evidence from the history, physical examination or laboratory findings that the disturbance is caused by the direct physiologic consequences of a general medical condition, substance intoxication, or withdrawal.
Delirium can be described as hyperactive, hypoactive or a mixed type.
Hyperactive delirium – restless, wandering, sometimes aggressive
Hypoactive delirium – decreased alertness, lethargic, apathy
Mixed type – combination of these
Risk Factors
Older age
Frailty
Dementia or cognitive impairment (known or underlying)
History of delirium
Co-existing medical illness
Visual/hearing impairment
Functional impairment/immobility
Decreased oral intake
Polypharmacy – particularly psychoctive medications
Surgery
Renal Impairment
Alcohol excess
Clinical Features
A thorough history and exam is necessary to help differentiate between an acute delirium and a dementia. Characteristic features of each are outlined below.
Symptoms
Acute, fluctuating change in behaviour
Patient lacking insight
Disorganised thinking
Poor sleep
Symptoms of underlying cause e.g. sepsis
NB patient may be confused and unable to accurately answer. Collateral history is imperative
Signs
Appearance
confused, picking at clothing or wires, restless, agitated, lack of concern for own nudity.
Abnormal vitals suggesting infective cause
Altered conscious state
Signs indicating cause of delirium
Meningitis – rash, neck stiffness, Kernigs + Brudzinksi’s sign
Chest – Crackles, wheeze
Abdomen – tenderness, diarrhoea, distension, hepatic flap
Urinary – flank tenderness
Skin/Soft tissue – swelling, erythema, tenderness
Tremor indicating ETOH withdrawal
Differential Diagnosis
Delirium is an acute behavioural disturbance that has many potential underlying causes. As a clinical syndrome it can also be confused with acute psychosis or dementia.
Infective
Urinary
Respiratory
Intra-abdominal
CNS - meningitis, encephalitis, abscess, neurosyphilis
Skin and soft tissue
Drugs
Alcohol - Wernickes, Withdrawal
Illicit drug intoxication or withdrawal
e.g. Cocaine, MDMA, caffeine, amphetamines, PCP
Adverse effects of prescription drugs
e.g. steroids, anticholinergics, TCA’s, Levodopa
Polypharmacy
Metabolic & Endocrine
Uraemia
Hyponatraemia
Hypercalcaemia
Hepatic encephalopathy
Hypo/Hyperthyroidism
Hypoglycaemia/Hyperglycaemia
Other
Constipation
Urinary Retention
Myocardial Infarction
CNS
Dementia
Stroke/TIA
Transient Global Amnesia
Seizure/Post-ictal
Intracerebral haemorrhage
Neoplasm
Psychiatric Disorders
Drug induced psychosis
Bipolar disorder
Schizophrenia
Depression
Post partum psychosis
Clinical Investigations
Delirium is a clinical diagnosis. The 4AT assessment test for delirium and cognitive impairment should be used by health provisionals to screen for delirium when the diagnosis is suspected. Clinical investigations thereafter should focus on seeking the underlying cause of the patients delirium.
Management & Disposition
Recognition
Delirium is poorly detected and documented in the ED.
Performance of routine assessment using 4 AT is a requirement for all patients aged ≥ 65years in our department
Seek & Treat
Identify and treat the underlying cause.
Aim to manage a patient with delirium as a matter of urgency. The ED environment can worsen and even precipitate an episode of delirium in those who are not delirious at initial presentation.
Prevention
Prevention of delirium is imperative. It is estimated that up to a third of cases are preventable.
Consider supervision
Ensure hearing aids and glasses are accessible
Regular orientation
Appropriate lighting for time of day, use of clocks
Family visits with objects from home
Regular analgesia if in pain
Use of urinary catheters and IV medications only if necessary
Prevent dehydration & constipation
Avoid Sedation
Avoid sedation unless patient represents a risk to themselves or others or is highly agitated or distressed. Every effort should be made to reassure and re-orientate the delirious patient and a family member should be encouraged to stay with them.
If sedation is absolutely necessary oral medication should be offered before parenteral medication if possible.
Always consider a patient’s age, weight, cardiac status, QT interval, heaptic and renal function prior to prescribing tranquilizers.
An example of First line therapy is;
Haloperidol 0.5-1mg PO and/or Lorazepam 0.5 - 1mg PO
If the patient is unwilling or unable to take PO the above medication can be given IM. Please consult your local prescribers guideline.
Disposition
The vast majority of patients with delirium will need to be admitted to hospital.
They should be flagged for admission early and be prioritised for an inpatient delirium friendly bed as prolonged stays in the loud, bright and chaotic environment of the ED can delay their recovery.
References
Pisani M. Evaluation of delirium | BMJ Best Practice US [Internet]. Bestpractice.bmj.com. 2019 [cited 8 March 2021]. Available from: https://bestpractice.bmj.com/topics/en-us/241
Gower L, Gatewood M, Kang C. Emergency Department Management of Delirium in the Elderly. Western Journal of Emergency Medicine. 2012;13(2):194-201.
Carpenter C, Shah M, Hustey F, Heard K, Gerson L, Miller D. High Yield Research Opportunities in Geriatric Emergency Medicine: Prehospital Care, Delirium, Adverse Drug Events, and Falls. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2011;66A(7):775-783.
Fordham S, Mann C. RCEM Learning Delirium in the elderly by Steve Fordham & Cliff Mann [Internet]. RCEMLearning. 2020 [cited 8 March 2021]. Available from: https://www.rcemlearning.co.uk/reference/delirium-in-the-elderly/#1568885317979-11992775-bf17
St James’s Hospital Prescribers Capsule
This blog was written by Dr Laura Quinn and was last updated in May 2021