Delirium

Introduction

Delirium is an acute, fluctuating change in mental status characterised by inattention, disorganized thinking and altered levels of consciousness.

Delirium represents approximately 15 % of ED presentations of older adults. A diagnosis of delirium in the ED infers a 12-month mortality rate of up to 25% which is comparable to patients with sepsis or acute myocardial infarction

The fluctuating course of delirium helps differentiate it from miId cognitive impairment and dementia. Obtaining a collateral history to determine baseline cognition is essential in the diagnosis.  

DSM 5 Criteria for Diagnosis

  1. A disturbance in attention is evident with reduced ability to focus, sustain, or shift attention.

  2. A change in cognition such as memory deficit, disorientation, language disturbance or the development of a perceptual disturbance not better accounted for by pre existing or evolving dementia

  3. The disturbance evolves over a short period of time (hours to days), represents an acute change from baseline and tends to fluctuate over the course of the day.

  4. There is evidence from the history, physical examination or laboratory findings that the disturbance is caused by the direct physiologic consequences of a general medical condition, substance intoxication, or withdrawal.

Delirium can be described as hyperactive, hypoactive or a mixed type.

  1. Hyperactive delirium – restless, wandering, sometimes aggressive

  2. Hypoactive delirium – decreased alertness, lethargic, apathy

  3. Mixed type – combination of these

Risk Factors

  • Older age

  • Frailty

  • Dementia or cognitive impairment (known or underlying)

  • History of delirium

  • Co-existing medical illness

  • Visual/hearing impairment

  • Functional impairment/immobility

  • Decreased oral intake

  • Polypharmacy – particularly psychoctive medications

  • Surgery

  • Renal Impairment

  • Alcohol excess

Clinical Features

 

A thorough history and exam is necessary to help differentiate between an acute delirium and a dementia. Characteristic features of each are outlined below.

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Symptoms

  • Acute, fluctuating change in behaviour

  • Patient lacking insight

  • Disorganised thinking

  • Poor sleep

  • Symptoms of underlying cause e.g. sepsis

    • NB patient may be confused and unable to accurately answer. Collateral history is imperative

Signs

  • Appearance

    • confused, picking at clothing or wires, restless, agitated, lack of concern for own nudity.

  • Abnormal vitals suggesting infective cause

  • Altered conscious state

  • Signs indicating cause of delirium

    • Meningitis – rash, neck stiffness, Kernigs + Brudzinksi’s sign

    • Chest – Crackles, wheeze

    • Abdomen – tenderness, diarrhoea, distension, hepatic flap

    • Urinary – flank tenderness

    • Skin/Soft tissue – swelling, erythema, tenderness

    • Tremor indicating ETOH withdrawal

Differential Diagnosis

 

Delirium is an acute behavioural disturbance that has many potential underlying causes. As a clinical syndrome it can also be confused with acute psychosis or dementia.

Infective

  • Urinary

  • Respiratory

  • Intra-abdominal

  • CNS - meningitis, encephalitis, abscess, neurosyphilis

  • Skin and soft tissue

 

Drugs

  • Alcohol - Wernickes, Withdrawal

  • Illicit drug intoxication or withdrawal

    • e.g. Cocaine, MDMA, caffeine, amphetamines, PCP

  • Adverse effects of prescription drugs

    • e.g. steroids, anticholinergics, TCA’s, Levodopa

  • Polypharmacy

Metabolic & Endocrine

  • Uraemia

  • Hyponatraemia

  • Hypercalcaemia

  • Hepatic encephalopathy

  • Hypo/Hyperthyroidism

  • Hypoglycaemia/Hyperglycaemia

 

Other

  • Constipation

  • Urinary Retention

  • Myocardial Infarction

CNS

  • Dementia

  • Stroke/TIA

  • Transient Global Amnesia

  • Seizure/Post-ictal

  • Intracerebral haemorrhage

  • Neoplasm

 

Psychiatric Disorders

  • Drug induced psychosis

  • Bipolar disorder

  • Schizophrenia

  • Depression

  • Post partum psychosis

Clinical Investigations

Delirium is a clinical diagnosis. The 4AT assessment test for delirium and cognitive impairment should be used by health provisionals to screen for delirium when the diagnosis is suspected. Clinical investigations thereafter should focus on seeking the underlying cause of the patients delirium.

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Bedside

Urinalysis

  • UTI’s are frequently but not always the precipitant of delirium. Leucocytes on dipstick do not out rule other causes.

ECG - ? Myocardial ischaemia, ? conduction disturbance

VBG - ? Acid base disturbance, hypoglycaemia, electrolyte abn

POCUS - ? urinary retention

 
bloods%2B%252B%2Bpod.jpg

Laboratory

FBC + CRP - Leucocytosis, elevated inflam markers ?possible infection

U&E - ? uraemia, hypo/hypernatraemia, ? hypo/hyperkalaemia

LFT - ? hepatic encephalopathy

Microbiology

  • culture blood, sputum, urine or CSF as clinically indicated

Other e.g. TFTs, drug levels

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Radiology

CXR

  • Routine in all delirious patients. ? Respiratory or cardiac cause underlying

CT Brian

  • If any suspicion of intracranial cause or history of trauma including simple falls.

  • If underlying cause for delirium is not clear there should be a low threshold for CT brain

Management & Disposition

 

Recognition

Delirium is poorly detected and documented in the ED.

Performance of routine assessment using 4 AT is a requirement for all patients aged ≥ 65years in our department


Seek & Treat

Identify and treat the underlying cause.

Aim to manage a patient with delirium as a matter of urgency. The ED environment can worsen and even precipitate an episode of delirium in those who are not delirious at initial presentation.

Prevention

Prevention of delirium is imperative. It is estimated that up to a third of cases are preventable.

  • Consider supervision

  • Ensure hearing aids and glasses are accessible

  • Regular orientation

  • Appropriate lighting for time of day, use of clocks

  • Family visits with objects from home

  • Regular analgesia if in pain

  • Use of urinary catheters and IV medications only if necessary

  • Prevent dehydration & constipation

Avoid Sedation

Avoid sedation unless patient represents a risk to themselves or others or is highly agitated or distressed. Every effort should be made to reassure and re-orientate the delirious patient and a family member should be encouraged to stay with them.

If sedation is absolutely necessary oral medication should be offered before parenteral medication if possible.

Always consider a patient’s age, weight, cardiac status, QT interval, heaptic and renal function prior to prescribing tranquilizers.

  • An example of First line therapy is;

    • Haloperidol  0.5-1mg PO and/or Lorazepam 0.5 - 1mg PO

  • If the patient is unwilling or unable to take PO the above medication can be given IM. Please consult your local prescribers guideline.

Disposition

The vast majority of patients with delirium will need to be admitted to hospital.

They should be flagged for admission early and be prioritised for an inpatient delirium friendly bed as prolonged stays in the loud, bright and chaotic environment of the ED can delay their recovery.

References

 

  1. Pisani M. Evaluation of delirium | BMJ Best Practice US [Internet]. Bestpractice.bmj.com. 2019 [cited 8 March 2021]. Available from: https://bestpractice.bmj.com/topics/en-us/241

  2. Gower L, Gatewood M, Kang C. Emergency Department Management of Delirium in the Elderly. Western Journal of Emergency Medicine. 2012;13(2):194-201.

  3. Carpenter C, Shah M, Hustey F, Heard K, Gerson L, Miller D. High Yield Research Opportunities in Geriatric Emergency Medicine: Prehospital Care, Delirium, Adverse Drug Events, and Falls. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2011;66A(7):775-783.

  4. Fordham S, Mann C. RCEM Learning Delirium in the elderly by Steve Fordham & Cliff Mann [Internet]. RCEMLearning. 2020 [cited 8 March 2021]. Available from: https://www.rcemlearning.co.uk/reference/delirium-in-the-elderly/#1568885317979-11992775-bf17

  5. St James’s Hospital Prescribers Capsule

This blog was written by Dr Laura Quinn and was last updated in May 2021

 Before you go have another look at the clinical case and see have your answers to any of the questions changed and if so how?