Haemorrhagic Shock

Introduction

Haemorrhagic shock is a type of hypovolaemic shock that occurs due to massive haemorrhage resulting in inadequate organ perfusion and tissue oxygenation. Common causes of haemorrhagic shock include major trauma, intra or postoperative haemorrhage, obstetric haemorrhage, aneurysm rupture and ectopic pregnancy rupture.

 

Massive haemorrhage is defined as one of;

  • Acute transfusion of 4 or more units of blood in 1 hr with ongoing haemorrhage

  • Loss of > 50% of blood volume in 3 hrs or less

  • Loss of 1 or more blood volumes within 24 hrs (5L blood in 70kg adult)

 

In the setting of trauma it is convenient to consider the potential source of haemorrhage using the mnemonic “On the Floor and Four More”

  • Floor – Major external wound e.g. scalp, arterial injury to a limb

  • Chest -  e.g. massive haemothorax, great vessel injury

  • Abdomen – e.g. Liver, spleen laceration, vessel injury

  • Pelvis/Retroperitoneum – e.g. pelvic fracture, kidney laceration

  • Long Bone Fracture – especially femur fracture

Clinical Features

 

Symptoms

  • Pain

    • suggesting source of bleeding e.g. abdomen, long bone, shoulder tip,

  • Respiratory

    • Shortness of Breath

  • Feeling cold, thirsty, wanting to change position constantly, urgent desire to open bowels

Signs

  • Signs of Shock

    • loss of airway, reduced GCS, hypoxia, tachypnoea, hypotension, tachycardia, pallor, reduced cap refill

  • Skin

    • bruising indicating source of bleeding, mottling

  • Resp

    • Signs of Massive haemothorax e.g decreased a/e, dull to percussion, tenderness

  • Abdomen

    • Signs of haemoperitoneum e.g. distension, tenderness, bruising, guarding

  • Pelvis

    • Genital bruising, blood at urinary meatus

  • Long Bone

    • compartment swelling, bruising, rotated limbs

Differential Diagnosis

Other causes of shock

  • Obstructive shock (2nd most common cause of shock in trauma)

  • Cardiogenic shock

    • e.g. myocardial contusion, secondary to severe traumatic brain injury

  • Neurogenic shock

    • secondary to traumatic spinal cord injury

  • Other causes of SIRS and vasodilatory or distributive shock

  • Septic Shock

  • Hypovolaemic shock secondary to dehydration

  • Anaphylactic shock

Clinical Investigations

 
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Bedside

  • VBG

    • Low pH, low base excess + high lactate are all indicators of haemorrhagic shock.

    • Haemoglobin has no diagnostic value in the early phase of massive haemorrhage as haemodilution as not occurred.

    • Monitor ionized calcium on VBG

  • eFAST

    • can identify source of bleeding (chest/abdomen).

    • Can out rule other causes of shock e.g. tension pneumothorax, tamponade

  • ECG - ? ST elevation

 
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Laboratory

  • FBC – Monitor Hb trend. Platelets very important for clotting

  • Group and Cross Match at least 6 units

  • Coag – Assess for & monitor development of coagulopathy

  • U&E, LFT, Amylase  - baseline trauma bloods

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Radiology

  • Portable CXR and Pelvic XR in resus post primary survey in the unstable patient

  • If patient stable CT as clinically indicated to identify injuries and guide further management

  • Plain films as clinically indicated in stable patient

Management & Disposition

 

Initial Resuscitation

  • Call for Help. Pt is critically unwell and will require lots of people to manage. Trauma patient should be managed by Trauma Team including (not limited to) ED, Surgeons and Anaesthesia/ICU

  • Declare “Massive Transfusion/Code Red”

  • Multiple (at least 2) wide bore access

  • Only fluid to be administered to ED patients with haemorrhagic shock is Blood Products

    • In the immediate setting = O negative Packed Red Blood Cells

Specific Treatment

  • Single most important treatment is Control & Stop the Bleeding

    • For internal haemorrhage = may involve urgent transfer to theatre or Interventional Radiology

    • Other ways to stop bleeding include pelvic binder, splinting long bones, direct pressure to bleeding wounds, application of tourniquets.

  • Damage Control Resuscitation (3 steps)

  1. Permissive Hypotension = Aiming for a BP that is high enough to adequately perfuse organs but low enough to reduce risk of dilutional coagulopathy and clot disruption. MAP of approx 65mmHg

  2. Haemostatic Resuscitation = Transfuse blood products (Red Cells + Plasma + Platelets) at ratio of 1:1:1.

    • Do not give crystalloid due to risk of causing coagulopathy

  3. Damage Control Surgery e.g. abdominal or pelvic packing to stop bleeding asap.

  • Avoid the Lethal Triad of;

1.     Hypothermia

2.     Acidosis

3.     Coagulopathy

  • IV Tranexamic Acid 1g bolus and 1g infusion within 3 hours of trauma

Disposition

  • Once bleeding has been controlled (either in ED, theatre or radiology) the patient should be admitted to ICU for ongoing coagulopathy treatment and organ support as required.

 

References

1.     Massive Blood Loss: Blood and Blood Product Replacement Guideline. SJH. LabMed Directorate, Department of Transfusion Medicine

2.     Managing Major Haemorrhage in the Emergency Department. Rcemlearning.co.uk

3.     Holcomb JB et al. The PROPPR randomized clinical trial. JAMA 2015

This blog was written by Dr Deirdre Glynn and was last updated in November 2020

 Before you go have another look at the clinical case and see have your answers to any of the questions changed and if so how?